The match will be the second of two games to be played in Spain during the mid-season break, and will kick off at 18.00 local time (17.00 GMT) on 10 December at the Estadio Benito Villamarin, Seville.
Following on from the team’s match against another local side, Cadiz CF on 7 December, both games will form part of United’s winter training camp in Cadiz, as Erik ten Hag prepares his remaining players for the restart of the Premier League in late December.
Manchester United’s football director, John Murtough, comments:
“We’re pleased to have lined up another match against high-quality local opposition during our stay in southern Spain.