The fifth-round tie is being held at the Kassam Stadium on Wednesday 18 February, kicking off at 18:00 GMT.
Ticket information and live television details will be supplied in due course.
It is a first game on the road for Darren Fletcher's side in this season's competition.
In round three, we saw off Peterborough United 1-0, with a goal from Gabriel, before overcoming Derby County 2-1, after extra-time. An own goal by Luca Crolla and calm finish by Chido Obi proved sufficient to progress, with both games being played at Old Trafford, providing wonderful experience for the youngsters.