The 2011/12 Sir Matt Busby Player of the Year is poised to turn out again for the team, in what promises to be a special day at St Mary's.
The match kicks off at 15:00 GMT on Saturday 28 March.
Almost 3,000 tickets in the away end have already been sold and you can get yours here.
Valencia played 339 times for the Reds, after arriving from Wigan Athletic in 2009.
Starring on the right wing and then after moving into a full-back slot, he remains extremely popular with our supporters.